Updated: Nov 17, 2021
Niners Welcome Chiefs for Preseason Opener
The quarterback battle with the San Francisco 49ers will be in the spotlight this Saturday when they host the Kansas City Chiefs in a rematch of Super Bowl LIV, kicking off at 8:30 PM ET. The Niners are favored by 2.5 points at press time with the total at 36.5.
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It will be interesting to see how San Francisco head coach Kyle Shanahan approaches this game. Jimmy Garoppolo remains their No. 1 QB, but third overall pick Trey Lance is expected to take over at some point. Meanwhile, we’ll might see Patrick Mahomes play the first series for Kansas City.